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Structural Basis for Diltiazem Block of a Voltage-Gated Ca(2+) Channel
Diltiazem is a widely prescribed Ca(2+) antagonist drug for cardiac arrhythmia, hypertension, and angina pectoris. Using the ancestral Ca(V) channel construct Ca(V)Ab as a molecular model for X-ray crystallographic analysis, we show here that diltiazem targets the central cavity of the voltage-gated...
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| Publicado no: | Mol Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6738535/ https://ncbi.nlm.nih.gov/pubmed/31391290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.117531 |
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