Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood

Heme is a critical danger molecule liberated from hemeproteins in various conditions, including from hemoglobin in hemolytic diseases. Heme may cause thromboinflammatory damage by activating inflammatory and hemostatic pathways, such as complement, the TLRs, coagulation, and platelets. In this study...

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Bibliografske podrobnosti
izdano v:J Immunol
Main Authors: Thomas, Anub M., Gerogianni, Alexandra, McAdam, Martin B., Fløisand, Yngvar, Lau, Corinna, Espevik, Terje, Nilsson, Per H., Mollnes, Tom Eirik, Barratt-Due, Andreas
Format: Artigo
Jezik:Inglês
Izdano: AAI 2019
Teme:
Innate Immunity and Inflammation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731449/
https://ncbi.nlm.nih.gov/pubmed/31413105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900047
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