Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood

Heme is a critical danger molecule liberated from hemeproteins in various conditions, including from hemoglobin in hemolytic diseases. Heme may cause thromboinflammatory damage by activating inflammatory and hemostatic pathways, such as complement, the TLRs, coagulation, and platelets. In this study...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Thomas, Anub M., Gerogianni, Alexandra, McAdam, Martin B., Fløisand, Yngvar, Lau, Corinna, Espevik, Terje, Nilsson, Per H., Mollnes, Tom Eirik, Barratt-Due, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: AAI 2019
Fag:
Innate Immunity and Inflammation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731449/
https://ncbi.nlm.nih.gov/pubmed/31413105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900047
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