Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood

Heme is a critical danger molecule liberated from hemeproteins in various conditions, including from hemoglobin in hemolytic diseases. Heme may cause thromboinflammatory damage by activating inflammatory and hemostatic pathways, such as complement, the TLRs, coagulation, and platelets. In this study...

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Опубликовано в: :J Immunol
Главные авторы: Thomas, Anub M., Gerogianni, Alexandra, McAdam, Martin B., Fløisand, Yngvar, Lau, Corinna, Espevik, Terje, Nilsson, Per H., Mollnes, Tom Eirik, Barratt-Due, Andreas
Формат: Artigo
Язык:Inglês
Опубликовано: AAI 2019
Предметы:
Innate Immunity and Inflammation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731449/
https://ncbi.nlm.nih.gov/pubmed/31413105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900047
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