Double Blockade of CD14 and Complement C5 Abolishes the Cytokine Storm and Improves Morbidity and Survival in Polymicrobial Sepsis in Mice

Sepsis and septic shock, caused by an excessive systemic host-inflammatory response, are associated with high morbidity and mortality. The complement system and TLRs provide important pattern recognition receptors initiating the cytokine storm by extensive cross-talk. We hypothesized that double blo...

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Detalhes bibliográficos
Main Authors: Huber-Lang, Markus, Barratt-Due, Andreas, Pischke, Søren E., Sandanger, Øystein, Nilsson, Per H., Nunn, Miles A., Denk, Stephanie, Gaus, Wilhelm, Espevik, Terje, Mollnes, Tom E.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2014
Assuntos:
Innate Immunity and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025614/
https://ncbi.nlm.nih.gov/pubmed/24790148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400341
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