Double Blockade of CD14 and Complement C5 Abolishes the Cytokine Storm and Improves Morbidity and Survival in Polymicrobial Sepsis in Mice

Sepsis and septic shock, caused by an excessive systemic host-inflammatory response, are associated with high morbidity and mortality. The complement system and TLRs provide important pattern recognition receptors initiating the cytokine storm by extensive cross-talk. We hypothesized that double blo...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Huber-Lang, Markus, Barratt-Due, Andreas, Pischke, Søren E., Sandanger, Øystein, Nilsson, Per H., Nunn, Miles A., Denk, Stephanie, Gaus, Wilhelm, Espevik, Terje, Mollnes, Tom E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: AAI 2014
Gaiak:
Innate Immunity and Inflammation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025614/
https://ncbi.nlm.nih.gov/pubmed/24790148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400341
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