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Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases—C3 or C5 emerge together with CD14 as promising targets

The host is protected by pattern recognition systems, including complement and TLRs, which are closely cross-talking. If improperly activated, these systems might induce tissue damage and disease. Inhibition of single downstream proinflammatory cytokines, such as TNF, IL-1β, and IL-6, have failed in...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Barratt-Due, Andreas, Pischke, Søren Erik, Nilsson, Per H., Espevik, Terje, Mollnes, Tom Eirik
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5166441/
https://ncbi.nlm.nih.gov/pubmed/27581539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3VMR0316-132R
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