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Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases—C3 or C5 emerge together with CD14 as promising targets

The host is protected by pattern recognition systems, including complement and TLRs, which are closely cross-talking. If improperly activated, these systems might induce tissue damage and disease. Inhibition of single downstream proinflammatory cytokines, such as TNF, IL-1β, and IL-6, have failed in...

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Bibliografski detalji
Izdano u:J Leukoc Biol
Glavni autori: Barratt-Due, Andreas, Pischke, Søren Erik, Nilsson, Per H., Espevik, Terje, Mollnes, Tom Eirik
Format: Artigo
Jezik:Inglês
Izdano: Society for Leukocyte Biology 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5166441/
https://ncbi.nlm.nih.gov/pubmed/27581539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3VMR0316-132R
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