Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood

Heme is a critical danger molecule liberated from hemeproteins in various conditions, including from hemoglobin in hemolytic diseases. Heme may cause thromboinflammatory damage by activating inflammatory and hemostatic pathways, such as complement, the TLRs, coagulation, and platelets. In this study...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Thomas, Anub M., Gerogianni, Alexandra, McAdam, Martin B., Fløisand, Yngvar, Lau, Corinna, Espevik, Terje, Nilsson, Per H., Mollnes, Tom Eirik, Barratt-Due, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2019
Assuntos:
Innate Immunity and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731449/
https://ncbi.nlm.nih.gov/pubmed/31413105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900047
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