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Double Blockade of CD14 and Complement C5 Abolishes the Cytokine Storm and Improves Morbidity and Survival in Polymicrobial Sepsis in Mice

Sepsis and septic shock, caused by an excessive systemic host-inflammatory response, are associated with high morbidity and mortality. The complement system and TLRs provide important pattern recognition receptors initiating the cytokine storm by extensive cross-talk. We hypothesized that double blo...

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Autori principali: Huber-Lang, Markus, Barratt-Due, Andreas, Pischke, Søren E., Sandanger, Øystein, Nilsson, Per H., Nunn, Miles A., Denk, Stephanie, Gaus, Wilhelm, Espevik, Terje, Mollnes, Tom E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: AAI 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025614/
https://ncbi.nlm.nih.gov/pubmed/24790148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400341
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