Double Blockade of CD14 and Complement C5 Abolishes the Cytokine Storm and Improves Morbidity and Survival in Polymicrobial Sepsis in Mice

Sepsis and septic shock, caused by an excessive systemic host-inflammatory response, are associated with high morbidity and mortality. The complement system and TLRs provide important pattern recognition receptors initiating the cytokine storm by extensive cross-talk. We hypothesized that double blo...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Huber-Lang, Markus, Barratt-Due, Andreas, Pischke, Søren E., Sandanger, Øystein, Nilsson, Per H., Nunn, Miles A., Denk, Stephanie, Gaus, Wilhelm, Espevik, Terje, Mollnes, Tom E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: AAI 2014
Soggetti:
Innate Immunity and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025614/
https://ncbi.nlm.nih.gov/pubmed/24790148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400341
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi