Chimeric Anti-CD14 IGG2/4 Hybrid Antibodies for Therapeutic Intervention in Pig and Human Models of Inflammation

CD14 is a key recognition molecule of innate immune responses, interacting with several TLRs. TLR signaling cross-talks extensively with the complement system, and combined CD14 and complement inhibition has been proved effective in attenuating inflammatory responses. Pig models of human diseases ha...

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Autors principals: Lau, Corinna, Gunnarsen, Kristin S., Høydahl, Lene S., Andersen, Jan Terje, Berntzen, Gøril, Pharo, Anne, Lindstad, Julie K., Ludviksen, Judith K., Brekke, Ole-Lars, Barratt-Due, Andreas, Nielsen, Erik Waage, Stokes, Christopher R., Espevik, Terje, Sandlie, Inger, Mollnes, Tom Eirik
Format: Artigo
Idioma:Inglês
Publicat: AAI 2013
Matèries:
Innate Immunity and Inflammation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804170/
https://ncbi.nlm.nih.gov/pubmed/24062486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301653
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