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Ions Modulate Key Interactions between pHLIP and Lipid Membranes

The pH-low insertion peptide (pHLIP) is used for targeted delivery of drug cargoes to acidic tissues such as tumors. The extracellular acidosis found in solid tumors triggers pHLIP to transition from a membrane-adsorbed state to fold into a transmembrane α-helix. Different factors influence the acid...

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Podrobná bibliografie
Vydáno v:Biophys J
Hlavní autoři: Westerfield, Justin, Gupta, Chitrak, Scott, Haden L., Ye, Yujie, Cameron, Alayna, Mertz, Blake, Barrera, Francisco N.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731387/
https://ncbi.nlm.nih.gov/pubmed/31422821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.07.034
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