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Aspartate Embedding Depth Affects pHLIP’s Insertion pKa

We have used the pHLIP(®) (pH Low Insertion Peptide) peptide family to study the role of aspartate embedding depth in pH-dependent transmembrane peptide insertion. pHLIP binds to the surface of a lipid bilayer as a largely unstructured monomer at neutral pH. When pH is lowered, pHLIP inserts spontan...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fendos, Justin, Barrera, Francisco N., Engelman, Donald M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075456/
https://ncbi.nlm.nih.gov/pubmed/23721379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400252k
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