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Aspartate Embedding Depth Affects pHLIP’s Insertion pKa
We have used the pHLIP(®) (pH Low Insertion Peptide) peptide family to study the role of aspartate embedding depth in pH-dependent transmembrane peptide insertion. pHLIP binds to the surface of a lipid bilayer as a largely unstructured monomer at neutral pH. When pH is lowered, pHLIP inserts spontan...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4075456/ https://ncbi.nlm.nih.gov/pubmed/23721379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400252k |
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