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Tuning the Insertion Properties of pHLIP

The pH (low) insertion peptide (pHLIP) has exceptional characteristics: at neutral pH it is an unstructured monomer in solution or when bound to lipid bilayer surfaces, and it inserts across a lipid bilayer as a monomeric alpha-helix at acidic pH. The peptide targets acidic tissues in vivo, and may...

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Bibliografiska uppgifter
Huvudupphovsmän: Musial-Siwek, Monika, Karabadzhak, Alexander, Andreev, Oleg A., Reshetnyak, Yana K., Engelman, Donald M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862812/
https://ncbi.nlm.nih.gov/pubmed/19766589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2009.08.023
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