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Targeting diseased tissues by pHLIP insertion at low cell surface pH

The discovery of the pH Low Insertion Peptides (pHLIPs®) provides an opportunity to develop imaging and drug delivery agents targeting extracellular acidity. Extracellular acidity is associated with many pathological states, such as those in cancer, ischemic stroke, neurotrauma, infection, laceratio...

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Detalhes bibliográficos
Main Authors: Andreev, Oleg A., Engelman, Donald M., Reshetnyak, Yana K.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952044/
https://ncbi.nlm.nih.gov/pubmed/24659971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00097
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