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pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation

We find that pH-(low)-insertion-peptide (pHLIP)-facilitated translocation of phalloidin, a cell-impermeable polar toxin, inhibits the proliferation of cancer cells in a pH-dependent fashion. The monomeric pHLIP inserts its C terminus across a membrane under slightly acidic conditions (pH 6–6.5), for...

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Xehetasun bibliografikoak
Egile Nagusiak: An, Ming, Wijesinghe, Dayanjali, Andreev, Oleg A., Reshetnyak, Yana K., Engelman, Donald M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996653/
https://ncbi.nlm.nih.gov/pubmed/21048084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014403107
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