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pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path

What are the molecular events that occur when a peptide inserts across a membrane or exits from it? Using the pH-triggered insertion of the pH low insertion peptide to enable kinetic analysis, we show that insertion occurs in several steps, with rapid (0.1 sec) interfacial helix formation, followed...

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Autors principals: Andreev, Oleg A., Karabadzhak, Alexander G., Weerakkody, Dhammika, Andreev, Gregory O., Engelman, Donald M., Reshetnyak, Yana K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840156/
https://ncbi.nlm.nih.gov/pubmed/20160113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914330107
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