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Ions Modulate Key Interactions between pHLIP and Lipid Membranes
The pH-low insertion peptide (pHLIP) is used for targeted delivery of drug cargoes to acidic tissues such as tumors. The extracellular acidosis found in solid tumors triggers pHLIP to transition from a membrane-adsorbed state to fold into a transmembrane α-helix. Different factors influence the acid...
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| Publicado no: | Biophys J |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6731387/ https://ncbi.nlm.nih.gov/pubmed/31422821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.07.034 |
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