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Protonation Enhances the Inherent Helix-Forming Propensity of pHLIP

[Image: see text] Cell-penetrating peptides (CPPs) can be potentially used in targeted delivery of therapeutic cargoes. However, their conformation in solution is poorly understood. We employed molecular dynamics simulations to probe the structural fluctuations of an anionic CPP, pH Low Insertion Pe...

詳細記述

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書誌詳細
出版年:ACS Omega
主要な著者: Gupta, Chitrak, Mertz, Blake
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2017
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709774/
https://ncbi.nlm.nih.gov/pubmed/29214239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b01371
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