The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of Na(V)1.5 and RyR2 function

Here we report the structure of the widely utilized calmodulin (CaM)-dependent protein kinase II (CaMKII) inhibitor KN93 bound to the Ca(2+)-sensing protein CaM. KN93 is widely believed to inhibit CaMKII by binding to the kinase. The CaM-KN93 interaction is significant as it can interfere with the i...

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Gepubliceerd in:Cell Calcium
Hoofdauteurs: Johnson, Christopher N., Pattanayek, Rekha, Potet, Franck, Rebbeck, Robyn T., Blackwell, Daniel J., Nikolaienko, Roman, Sequeira, Vasco, Le Meur, Remy, Radwański, Przemysław B., Davis, Jonathan P., Zima, Aleksey V., Cornea, Razvan L., Damo, Steven M., Györke, Sandor, George, Alfred L., Knollmann, Bjorn C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708471/
https://ncbi.nlm.nih.gov/pubmed/31401388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2019.102063
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