Human ESC-derived chimeric mouse models of Huntington disease reveal cell-intrinsic defects in glial progenitor cell differentiation

Huntington’s disease (HD) is characterized by hypomyelination as well as neuronal loss. To assess the basis for myelin loss in HD, we generated bipotential glial progenitor cells (GPCs) from human embryonic stem cells (hESCs), derived from huntingtin (mHTT)-mutant embryos or normal controls, and per...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Osipovitch, Mikhail, Asenjo-Martinez, Andrea, Mariani, John N., Cornwell, Adam, Dhaliwal, Simrat, Zou, Lisa, Chandler-Militello, Devin, Wang, Su, Li, Xiaojie, Benraiss, Sarah-Jehanne, Agate, Robert, Lampp, Andrea, Benraiss, Abdellatif, Windrem, Martha S., Goldman, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700734/
https://ncbi.nlm.nih.gov/pubmed/30554964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.11.010
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados