Human glia can both induce and rescue aspects of disease phenotype in Huntington disease

The causal contribution of glial pathology to Huntington disease (HD) has not been heavily explored. To define the contribution of glia to HD, we established human HD glial chimeras by neonatally engrafting immunodeficient mice with mutant huntingtin (mHTT)-expressing human glial progenitor cells (h...

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Publicado no:Nat Commun
Main Authors: Benraiss, Abdellatif, Wang, Su, Herrlinger, Stephanie, Li, Xiaojie, Chandler-Militello, Devin, Mauceri, Joseph, Burm, Hayley B., Toner, Michael, Osipovitch, Mikhail, Jim Xu, Qiwu, Ding, Fengfei, Wang, Fushun, Kang, Ning, Kang, Jian, Curtin, Paul C., Brunner, Daniela, Windrem, Martha S., Munoz-Sanjuan, Ignacio, Nedergaard, Maiken, Goldman, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899632/
https://ncbi.nlm.nih.gov/pubmed/27273432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11758
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