Human glia can both induce and rescue aspects of disease phenotype in Huntington disease

The causal contribution of glial pathology to Huntington disease (HD) has not been heavily explored. To define the contribution of glia to HD, we established human HD glial chimeras by neonatally engrafting immunodeficient mice with mutant huntingtin (mHTT)-expressing human glial progenitor cells (h...

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Publicat a:Nat Commun
Autors principals: Benraiss, Abdellatif, Wang, Su, Herrlinger, Stephanie, Li, Xiaojie, Chandler-Militello, Devin, Mauceri, Joseph, Burm, Hayley B., Toner, Michael, Osipovitch, Mikhail, Jim Xu, Qiwu, Ding, Fengfei, Wang, Fushun, Kang, Ning, Kang, Jian, Curtin, Paul C., Brunner, Daniela, Windrem, Martha S., Munoz-Sanjuan, Ignacio, Nedergaard, Maiken, Goldman, Steven A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899632/
https://ncbi.nlm.nih.gov/pubmed/27273432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11758
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