Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's Disease

Huntington's disease (HD) is a neurodegenerative disease characterized in part by the loss of striatopallidal medium spiny projection neurons (MSNs). Expression of BDNF and noggin via intracerebroventricular (ICV) delivery in an adenoviral vector triggers the addition of new neurons to the neos...

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Main Authors: Benraiss, Abdellatif, Toner, Michael J., Xu, Qiwu, Bruel-Jungerman, Elodie, Rogers, Eloise H., Wang, Fushun, Economides, Aris N., Davidson, Beverly L., Kageyama, Ryoichiro, Nedergaard, Maiken, Goldman, Steven A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051319/
https://ncbi.nlm.nih.gov/pubmed/23746982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.04.014
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