Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease

Ependymal overexpression of brain-derived neurotrophic factor (BDNF) stimulates neuronal addition to the adult striatum, from subependymal progenitor cells. Noggin, by suppressing subependymal gliogenesis and increasing progenitor availability, potentiates this process. We asked whether BDNF/Noggin...

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Dades bibliogràfiques
Autors principals: Cho, Sung-Rae, Benraiss, Abdellatif, Chmielnicki, Eva, Samdani, Amer, Economides, Aris, Goldman, Steven A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2007
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978427/
https://ncbi.nlm.nih.gov/pubmed/17885687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31778
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