Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease

Ependymal overexpression of brain-derived neurotrophic factor (BDNF) stimulates neuronal addition to the adult striatum, from subependymal progenitor cells. Noggin, by suppressing subependymal gliogenesis and increasing progenitor availability, potentiates this process. We asked whether BDNF/Noggin...

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Bibliographic Details
Main Authors: Cho, Sung-Rae, Benraiss, Abdellatif, Chmielnicki, Eva, Samdani, Amer, Economides, Aris, Goldman, Steven A.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978427/
https://ncbi.nlm.nih.gov/pubmed/17885687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31778
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