Human ESC-derived chimeric mouse models of Huntington disease reveal cell-intrinsic defects in glial progenitor cell differentiation

Huntington’s disease (HD) is characterized by hypomyelination as well as neuronal loss. To assess the basis for myelin loss in HD, we generated bipotential glial progenitor cells (GPCs) from human embryonic stem cells (hESCs), derived from huntingtin (mHTT)-mutant embryos or normal controls, and per...

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Detaylı Bibliyografya
Yayımlandı:Cell Stem Cell
Asıl Yazarlar: Osipovitch, Mikhail, Asenjo-Martinez, Andrea, Mariani, John N., Cornwell, Adam, Dhaliwal, Simrat, Zou, Lisa, Chandler-Militello, Devin, Wang, Su, Li, Xiaojie, Benraiss, Sarah-Jehanne, Agate, Robert, Lampp, Andrea, Benraiss, Abdellatif, Windrem, Martha S., Goldman, Steven A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700734/
https://ncbi.nlm.nih.gov/pubmed/30554964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.11.010
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