Human ESC-derived chimeric mouse models of Huntington disease reveal cell-intrinsic defects in glial progenitor cell differentiation

Huntington’s disease (HD) is characterized by hypomyelination as well as neuronal loss. To assess the basis for myelin loss in HD, we generated bipotential glial progenitor cells (GPCs) from human embryonic stem cells (hESCs), derived from huntingtin (mHTT)-mutant embryos or normal controls, and per...

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Bibliografiske detaljer
Udgivet i:Cell Stem Cell
Main Authors: Osipovitch, Mikhail, Asenjo-Martinez, Andrea, Mariani, John N., Cornwell, Adam, Dhaliwal, Simrat, Zou, Lisa, Chandler-Militello, Devin, Wang, Su, Li, Xiaojie, Benraiss, Sarah-Jehanne, Agate, Robert, Lampp, Andrea, Benraiss, Abdellatif, Windrem, Martha S., Goldman, Steven A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700734/
https://ncbi.nlm.nih.gov/pubmed/30554964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.11.010
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