Structural basis for ligand recognition at the human MT(1) melatonin receptor

Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains circadian rhythm(1) by synchronization to environmental cues and is involved in diverse physiological processes(2) including blood pressure and core body temperature regulation, oncogenesis, and immune function(3). Formed in t...

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Published in:Nature
Main Authors: Stauch, Benjamin, Johansson, Linda C., McCorvy, John D., Patel, Nilkanth, Han, Gye Won, Huang, Xi-Ping, Gati, Cornelius, Batyuk, Alexander, Slocum, Samuel T., Ishchenko, Andrii, Brehm, Wolfgang, White, Thomas A., Michaelian, Nairie, Madsen, Caleb, Zhu, Lan, Grant, Thomas D., Grandner, Jessica M., Shiriaeva, Anna, Olsen, Reid H.J., Tribo, Alexandra R., Yous, Saïd, Stevens, Raymond C., Weierstall, Uwe, Katritch, Vsevolod, Roth, Bryan L., Liu, Wei, Cherezov, Vadim
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6696938/
https://ncbi.nlm.nih.gov/pubmed/31019306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1141-3
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