Toward G protein-coupled receptor structure-based drug design using X-ray lasers

Rational structure-based drug design (SBDD) relies on the availability of a large number of co-crystal structures to map the ligand-binding pocket of the target protein and use this information for lead-compound optimization via an iterative process. While SBDD has proven successful for many drug-di...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:IUCrJ
Main Authors: Ishchenko, Andrii, Stauch, Benjamin, Han, Gye Won, Batyuk, Alexander, Shiriaeva, Anna, Li, Chufeng, Zatsepin, Nadia, Weierstall, Uwe, Liu, Wei, Nango, Eriko, Nakane, Takanori, Tanaka, Rie, Tono, Kensuke, Joti, Yasumasa, Iwata, So, Moraes, Isabel, Gati, Cornelius, Cherezov, Vadim
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2019
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830214/
https://ncbi.nlm.nih.gov/pubmed/31709066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252519013137
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