Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

In mammals, ∼100 deubiquitinases act on ∼20,000 intracellular ubiquitination sites. Deubiquitinases are commonly regarded as constitutively active, with limited regulatory and targeting capacity. The BRCA1-A and BRISC complexes serve in DNA double-strand break repair and immune signaling and contain...

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Udgivet i:Mol Cell
Main Authors: Rabl, Julius, Bunker, Richard D., Schenk, Andreas D., Cavadini, Simone, Gill, Mark E., Abdulrahman, Wassim, Andrés-Pons, Amparo, Luijsterburg, Martijn S., Ibrahim, Adel F.M., Branigan, Emma, Aguirre, Jacob D., Marceau, Aimee H., Guérillon, Claire, Bouwmeester, Tewis, Hassiepen, Ulrich, Peters, Antoine H.F.M., Renatus, Martin, Gelman, Laurent, Rubin, Seth M., Mailand, Niels, van Attikum, Haico, Hay, Ronald T., Thomä, Nicolas H.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695476/
https://ncbi.nlm.nih.gov/pubmed/31253574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.002
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