DNA damage detection in nucleosomes involves DNA register shifting

Access to DNA packaged in nucleosomes is critical for gene regulation, DNA replication and repair. In humans, the UV-DDB complex detects ultraviolet light induced pyrimidine dimers throughout the genome, yet it remains unknown how these lesions are recognised in chromatin, where nucleosomes restrict...

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Publicat a:Nature
Autors principals: Matsumoto, Syota, Cavadini, Simone, Bunker, Richard D., Grand, Ralph S., Potenza, Alessandro, Rabl, Julius, Yamamoto, Junpei, Schenk, Andreas D., Schübeler, Dirk, Iwai, Shigenori, Sugasawa, Kaoru, Kurumizaka, Hitoshi, Thomä, Nicolas H.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611726/
https://ncbi.nlm.nih.gov/pubmed/31142837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1259-3
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