Structural basis of pyrimidine-pyrimidone (6–4) photoproduct recognition by UV-DDB in the nucleosome

UV-DDB, an initiation factor for the nucleotide excision repair pathway, recognizes 6–4PP lesions through a base flipping mechanism. As genomic DNA is almost entirely accommodated within nucleosomes, the flipping of the 6–4PP bases is supposed to be extremely difficult if the lesion occurs in a nucl...

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Publicado no:Sci Rep
Main Authors: Osakabe, Akihisa, Tachiwana, Hiroaki, Kagawa, Wataru, Horikoshi, Naoki, Matsumoto, Syota, Hasegawa, Mayu, Matsumoto, Naoyuki, Toga, Tatsuya, Yamamoto, Junpei, Hanaoka, Fumio, Thomä, Nicolas H., Sugasawa, Kaoru, Iwai, Shigenori, Kurumizaka, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648065/
https://ncbi.nlm.nih.gov/pubmed/26573481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16330
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