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SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites

SUMOylation plays important roles in the DNA damage response. However, whether it is important for interstrand crosslink repair remains unknown. We report that the SLX4 nuclease scaffold protein is regulated by SUMOylation. We have identified three SUMO interaction motifs (SIMs) in SLX4, mutating al...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO Rep
Prif Awduron: González-Prieto, Román, Cuijpers, Sabine AG, Luijsterburg, Martijn S, van Attikum, Haico, Vertegaal, Alfred CO
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BlackWell Publishing Ltd 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388617/
https://ncbi.nlm.nih.gov/pubmed/25722289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201440017
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