A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

The ubiquitin ligases RNF8 and RNF168 orchestrate DNA damage signalling through the ubiquitylation of histone H2A and the recruitment of downstream repair factors. Here, we demonstrate that RNF8, but not RNF168 or the canonical H2A ubiquitin ligase RNF2, mediates extensive chromatin decondensation....

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Detalhes bibliográficos
Main Authors: Luijsterburg, Martijn S, Acs, Klara, Ackermann, Leena, Wiegant, Wouter W, Bekker-Jensen, Simon, Larsen, Dorthe H, Khanna, Kum Kum, van Attikum, Haico, Mailand, Niels, Dantuma, Nico P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365417/
https://ncbi.nlm.nih.gov/pubmed/22531782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.104
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