A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

DNA double-strand breaks (DSB) elicit a ubiquitylation cascade that controls DNA repair pathway choice. This cascade involves the ubiquitylation of histone H2A by the RNF168 ligase and the subsequent recruitment of RIF1, which suppresses homologous recombination (HR) in G1 cells. The RIF1-dependent...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Luijsterburg, Martijn S, Typas, Dimitris, Caron, Marie-Christine, Wiegant, Wouter W, van den Heuvel, Diana, Boonen, Rick A, Couturier, Anthony M, Mullenders, Leon H, Masson, Jean-Yves, van Attikum, Haico
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328590/
https://ncbi.nlm.nih.gov/pubmed/28240985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.20922
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