Ataxin‐3 consolidates the MDC1‐dependent DNA double‐strand break response by counteracting the SUMO‐targeted ubiquitin ligase RNF4

The SUMO‐targeted ubiquitin ligase RNF4 functions at the crossroads of the SUMO and ubiquitin systems. Here, we report that the deubiquitylation enzyme (DUB) ataxin‐3 counteracts RNF4 activity during the DNA double‐strand break (DSB) response. We find that ataxin‐3 negatively regulates ubiquitylatio...

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Detalles Bibliográficos
Publicado en:EMBO J
Main Authors: Pfeiffer, Annika, Luijsterburg, Martijn S, Acs, Klara, Wiegant, Wouter W, Helfricht, Angela, Herzog, Laura K, Minoia, Melania, Böttcher, Claudia, Salomons, Florian A, van Attikum, Haico, Dantuma, Nico P
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391139/
https://ncbi.nlm.nih.gov/pubmed/28275011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695151
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