Ataxin‐3 consolidates the MDC1‐dependent DNA double‐strand break response by counteracting the SUMO‐targeted ubiquitin ligase RNF4

The SUMO‐targeted ubiquitin ligase RNF4 functions at the crossroads of the SUMO and ubiquitin systems. Here, we report that the deubiquitylation enzyme (DUB) ataxin‐3 counteracts RNF4 activity during the DNA double‐strand break (DSB) response. We find that ataxin‐3 negatively regulates ubiquitylatio...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Pfeiffer, Annika, Luijsterburg, Martijn S, Acs, Klara, Wiegant, Wouter W, Helfricht, Angela, Herzog, Laura K, Minoia, Melania, Böttcher, Claudia, Salomons, Florian A, van Attikum, Haico, Dantuma, Nico P
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391139/
https://ncbi.nlm.nih.gov/pubmed/28275011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695151
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados