Hsp70 and DNAJA2 limit CFTR levels through degradation

Cystic Fibrosis is caused by mutations in the CFTR anion channel, many of which cause its misfolding and degradation. CFTR folding depends on the Hsc70 and Hsp70 chaperones and their co-chaperone DNAJA1, but Hsc70/Hsp70 is also involved in CFTR degradation. Here, we address how these opposing functi...

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Udgivet i:PLoS One
Main Authors: Kim Chiaw, Patrick, Hantouche, Christine, Wong, Michael J. H., Matthes, Elizabeth, Robert, Renaud, Hanrahan, John W., Shrier, Alvin, Young, Jason C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692068/
https://ncbi.nlm.nih.gov/pubmed/31408507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220984
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