Hsp70 and DNAJA2 limit CFTR levels through degradation

Cystic Fibrosis is caused by mutations in the CFTR anion channel, many of which cause its misfolding and degradation. CFTR folding depends on the Hsc70 and Hsp70 chaperones and their co-chaperone DNAJA1, but Hsc70/Hsp70 is also involved in CFTR degradation. Here, we address how these opposing functi...

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Опубликовано в: :PLoS One
Главные авторы: Kim Chiaw, Patrick, Hantouche, Christine, Wong, Michael J. H., Matthes, Elizabeth, Robert, Renaud, Hanrahan, John W., Shrier, Alvin, Young, Jason C.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2019
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692068/
https://ncbi.nlm.nih.gov/pubmed/31408507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220984
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