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Hsp70 and DNAJA2 limit CFTR levels through degradation

Cystic Fibrosis is caused by mutations in the CFTR anion channel, many of which cause its misfolding and degradation. CFTR folding depends on the Hsc70 and Hsp70 chaperones and their co-chaperone DNAJA1, but Hsc70/Hsp70 is also involved in CFTR degradation. Here, we address how these opposing functi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kim Chiaw, Patrick, Hantouche, Christine, Wong, Michael J. H., Matthes, Elizabeth, Robert, Renaud, Hanrahan, John W., Shrier, Alvin, Young, Jason C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692068/
https://ncbi.nlm.nih.gov/pubmed/31408507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220984
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