Hsp40 Chaperones Promote Degradation of the hERG Potassium Channel

Loss of function mutations in the hERG (human ether-a-go-go related gene or KCNH2) potassium channel underlie the proarrhythmic cardiac long QT syndrome type 2. Most often this is a consequence of defective trafficking of hERG mutants to the cell surface, with channel retention and degradation at th...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Walker, Valerie E., Wong, Michael J. H., Atanasiu, Roxana, Hantouche, Christine, Young, Jason C., Shrier, Alvin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Molecular Basis of Cell and Developmental Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823420/
https://ncbi.nlm.nih.gov/pubmed/19940115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024000
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares