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Hsp40 Chaperones Promote Degradation of the hERG Potassium Channel

Loss of function mutations in the hERG (human ether-a-go-go related gene or KCNH2) potassium channel underlie the proarrhythmic cardiac long QT syndrome type 2. Most often this is a consequence of defective trafficking of hERG mutants to the cell surface, with channel retention and degradation at th...

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Bibliografiske detaljer
Main Authors: Walker, Valerie E., Wong, Michael J. H., Atanasiu, Roxana, Hantouche, Christine, Young, Jason C., Shrier, Alvin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823420/
https://ncbi.nlm.nih.gov/pubmed/19940115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024000
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