Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels

Cardiac long QT syndrome type 2 is caused by mutations in the human ether a go-go-related gene (hERG) potassium channel, many of which cause misfolding and degradation at the endoplasmic reticulum instead of normal trafficking to the cell surface. The Hsc70/Hsp70 chaperones assist the folding of the...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Hantouche, Christine, Williamson, Brittany, Valinsky, William C., Solomon, Joshua, Shrier, Alvin, Young, Jason C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Protein Synthesis and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313101/
https://ncbi.nlm.nih.gov/pubmed/27998983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752618
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