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Antidepressant-induced Ubiquitination and Degradation of the Cardiac Potassium Channel hERG

The most common cause for adverse cardiac events by antidepressants is acquired long QT syndrome (acLQTS), which produces electrocardiographic abnormalities that have been associated with syncope, torsade de pointes arrhythmias, and sudden cardiac death. acLQTS is often caused by direct block of the...

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Detalhes bibliográficos
Main Authors: Dennis, Adrienne T., Nassal, Drew, Deschenes, Isabelle, Thomas, Dierk, Ficker, Eckhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190784/
https://ncbi.nlm.nih.gov/pubmed/21832094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.254367
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