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Molecular Determinants of Pentamidine-Induced hERG Trafficking Inhibition
Pentamidine is an antiprotozoal compound that clinically causes acquired long QT syndrome (acLQTS), which is associated with prolonged QT intervals, tachycardias, and sudden cardiac arrest. Pentamidine delays terminal repolarization in human heart by acutely blocking cardiac inward rectifier current...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3263949/ https://ncbi.nlm.nih.gov/pubmed/22046004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.075135 |
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