The molecular determinants of R-roscovitine block of hERG channels

Human ether-à-go-go-related gene (Kv11.1, or hERG) is a potassium channel that conducts the delayed rectifier potassium current (I(Kr)) during the repolarization phase of cardiac action potentials. hERG channels have a larger pore than other K(+)channels and can trap many unintended drugs, often res...

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Udgivet i:PLoS One
Main Authors: Cernuda, Bryan, Fernandes, Christopher Thomas, Allam, Salma Mohamed, Orzillo, Matthew, Suppa, Gabrielle, Chia Chang, Zuleen, Athanasopoulos, Demosthenes, Buraei, Zafir
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719874/
https://ncbi.nlm.nih.gov/pubmed/31479461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217733
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