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Mechanism of Block of the hERG K(+) Channel by the Scorpion Toxin CnErg1
The scorpion toxin CnErg1 binds to human ether-a-go-go related gene (hERG) K(+) channels with a 1:1 stoichiometry and high affinity. However, in contrast to other scorpion toxin-ion channel interactions, the inhibition of macroscopic hERG currents by high concentrations of CnErg1 is incomplete. In t...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Biophysical Society
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1868980/ https://ncbi.nlm.nih.gov/pubmed/17369411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.101956 |
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