Probing the Outer Mouth Structure of the hERG Channel with Peptide Toxin Footprinting and Molecular Modeling

Previous studies have shown that the unusually long S5-P linker lining human ether a-go-go related gene's (hERG's) outer vestibule is critical for its channel function: point mutations at high-impact positions here can interfere with the inactivation process and, in many cases, also reduce...

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Bibliographic Details
Main Authors: Tseng, Gea-Ny, Sonawane, Kailas D., Korolkova, Yuliya V., Zhang, Mei, Liu, Jie, Grishin, Eugene V., Guy, H. Robert
Format: Artigo
Language:Inglês
Published: Biophysical Society 2007
Subjects:
Channels, Receptors, and Electrical Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853143/
https://ncbi.nlm.nih.gov/pubmed/17293393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.097360
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