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State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy
Human ether-a-go-go-related gene (HERG) potassium channel acts as a delayed rectifier in cardiac myocytes and is an important target for both pro- and antiarrhythmic drugs. Many drugs have been pulled from the market for unintended HERG block causing arrhythmias. Conversely, recent evidence has show...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Physiological Society
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2670659/ https://ncbi.nlm.nih.gov/pubmed/19244476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00633.2008 |
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