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Pentamidine reduces hERG expression to prolong the QT interval
1. Pentamidine, an antiprotozoal agent, has been traditionally known to cause QT prolongation and arrhythmias; however, its ionic mechanism has not been illustrated. 2. In a stable HEK-293 cell line, we observed a concentration-dependent inhibition of the hERG current with an IC(50) of 252 μM. 3. In...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1576113/ https://ncbi.nlm.nih.gov/pubmed/15711592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706140 |
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