Pentamidine reduces hERG expression to prolong the QT interval

1. Pentamidine, an antiprotozoal agent, has been traditionally known to cause QT prolongation and arrhythmias; however, its ionic mechanism has not been illustrated. 2. In a stable HEK-293 cell line, we observed a concentration-dependent inhibition of the hERG current with an IC(50) of 252 μM. 3. In...

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Bibliographische Detailangaben
Hauptverfasser: Cordes, Jason S, Sun, Zhuoqian, Lloyd, David B, Bradley, Jenifer A, Opsahl, Alan C, Tengowski, Mark W, Chen, Xian, Zhou, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576113/
https://ncbi.nlm.nih.gov/pubmed/15711592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706140
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