Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block

Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and addiction. QT(C) prolongation that crosses the 10 msec threshold of regulatory concern was observed at a supratherapeutic dose in two thorough QT studies for the transdermal buprenorphine product BUTRANS(®). Because Q...

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發表在:PLoS One
Main Authors: Tran, Phu N., Sheng, Jiansong, Randolph, Aaron L., Baron, Claudia Alvarez, Thiebaud, Nicolas, Ren, Ming, Wu, Min, Johannesen, Lars, Volpe, Donna A., Patel, Dakshesh, Blinova, Ksenia, Strauss, David G., Wu, Wendy W.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2020
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7647070/
https://ncbi.nlm.nih.gov/pubmed/33157550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0241362
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