Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block

Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and addiction. QT(C) prolongation that crosses the 10 msec threshold of regulatory concern was observed at a supratherapeutic dose in two thorough QT studies for the transdermal buprenorphine product BUTRANS(®). Because Q...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tran, Phu N., Sheng, Jiansong, Randolph, Aaron L., Baron, Claudia Alvarez, Thiebaud, Nicolas, Ren, Ming, Wu, Min, Johannesen, Lars, Volpe, Donna A., Patel, Dakshesh, Blinova, Ksenia, Strauss, David G., Wu, Wendy W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7647070/
https://ncbi.nlm.nih.gov/pubmed/33157550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0241362
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados