The l-isoaspartate modification within protein fragments in the aging lens can promote protein aggregation

Transparency in the lens is accomplished by the dense packing and short-range order interactions of the crystallin proteins in fiber cells lacking organelles. These features are accompanied by a lack of protein turnover, leaving lens proteins susceptible to a number of damaging modifications and agg...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Warmack, Rebeccah A., Shawa, Harrison, Liu, Kate, Lopez, Katia, Loo, Joseph A., Horwitz, Joseph, Clarke, Steven G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2019
Onderwerpen:
Protein Synthesis and Degradation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690693/
https://ncbi.nlm.nih.gov/pubmed/31239355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009052
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