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The l-isoaspartate modification within protein fragments in the aging lens can promote protein aggregation
Transparency in the lens is accomplished by the dense packing and short-range order interactions of the crystallin proteins in fiber cells lacking organelles. These features are accompanied by a lack of protein turnover, leaving lens proteins susceptible to a number of damaging modifications and agg...
Enregistré dans:
| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6690693/ https://ncbi.nlm.nih.gov/pubmed/31239355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009052 |
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